eNAMPT/TLR4 inflammatory cascade activation is a key contributor to SLE Lung vasculitis and alveolar hemorrhage

eNAMPT/TLR4 inflammatory cascade activation is a key contributor to SLE Lung vasculitis and alveolar hemorrhage

Rationale: Effective therapies to reduce the severity and high mortality of pulmonary vasculitis and diffuse alveolar hemorrhage (DAH) in patients with systemic lupus erythematosus (SLE) is a serious unmet need. We explored whether biologic neutralization of eNAMPT (extracellular nicotinamide phosph...

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Bibliographic Details
Main Authors: Gantsetseg Tumurkhuu, Nancy G. Casanova, Carrie L. Kempf, Duygu Ercan Laguna, Sara M. Camp, Jargalsaikhan Dagvadorj, Jin H. Song, Vivian Reyes Hernon, Cristina Travelli, Erica N. Montano, Jeong Min Yu, Mariko Ishimori, Daniel J. Wallace, Saad Sammani, Caroline Jefferies, Joe G.N. Garcia
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Journal of Translational Autoimmunity
Subjects:
eNAMPT
DAMP
SLE
Pulmonary vasculitis
DAH
Pristane
Online Access:http://www.sciencedirect.com/science/article/pii/S2589909022000429

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http://www.sciencedirect.com/science/article/pii/S2589909022000429

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