Ultrasound-mediated rapamycin delivery for promoting osseointegration of 3D printed prosthetic interfaces via autophagy regulation in osteoporosis

Ultrasound-mediated rapamycin delivery for promoting osseointegration of 3D printed prosthetic interfaces via autophagy regulation in osteoporosis

Osteoporosis-derived bone marrow mesenchymal stem cells (OP-BMSCs) have impaired cell function, low osteogenic activity, and potential osteoclast inducibility, resulting in insufficient osseointegration and increased risk of catastrophic postoperative complications after arthroplasty. The low autoph...

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Bibliographic Details
Main Authors: Zuhao Li, Haotian Bai, Zhonghan Wang, Yuzhe Liu, Ming Ren, Xiangang Wang, Weinan Gao, Qiuju Li, Minfei Wu, He Liu, Jincheng Wang
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Materials & Design
Subjects:
3D printed prosthetic interface
Autophagy
Osteoporosis
Osseointegration
Rapamycin
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127522002076

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http://www.sciencedirect.com/science/article/pii/S0264127522002076

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