The synovial fluid fibroblast-like synoviocyte: A long-neglected piece in the puzzle of rheumatoid arthritis pathogenesis
Rheumatoid arthritis (RA) is a systemic autoimmune disease during which fibroblast-like synoviocytes (FLS) contribute to both joint inflammation and destruction. FLS represent the core component of the synovial membrane. Following inflammation of this membrane, an effusion of cell-rich synovial flui...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.942417/full |
| _version_ | 1828188569048449024 |
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| author | Dorra Elhaj Mahmoud Dorra Elhaj Mahmoud Wajih Kaabachi Nadia Sassi Lamjed Tarhouni Sonia Rekik Samia Jemmali Hela Sehli Maryam Kallel-Sellami Elhem Cheour Lilia Laadhar |
| author_facet | Dorra Elhaj Mahmoud Dorra Elhaj Mahmoud Wajih Kaabachi Nadia Sassi Lamjed Tarhouni Sonia Rekik Samia Jemmali Hela Sehli Maryam Kallel-Sellami Elhem Cheour Lilia Laadhar |
| author_sort | Dorra Elhaj Mahmoud |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a systemic autoimmune disease during which fibroblast-like synoviocytes (FLS) contribute to both joint inflammation and destruction. FLS represent the core component of the synovial membrane. Following inflammation of this membrane, an effusion of cell-rich synovial fluid (SF) fills the joint cavity. Unlikely, SF has been shown to contain fibroblasts with some shared phenotypic traits with the synovial membrane FLS. These cells are called SF-FLS and their origin is still unclear. They are either brought into the synovium via migration through blood vessels, or they could originate within the synovium and exist in projections of the synovial membrane. SF-FLS function and phenotype are poorly documented compared to recently well-characterized synovial membrane FLS subsets. Furthermore, no study has yet reported a SF-FLS single-cell profiling analysis. This review will discuss the origin and cellular characteristics of SF-FLS in patients with RA. In addition, recent advances on the involvement of SF-FLS in the pathogenesis of RA will be summarized. Current knowledge on possible relationships between SF-FLS and other types of fibroblasts, including synovial membrane FLS, circulating fibrocytes, and pre- inflammatory mesenchymal (PRIME) cells will also be addressed. Finally, recent therapeutic strategies employed to specifically target SF-FLS in RA will be discussed. |
| first_indexed | 2024-04-12T07:51:24Z |
| format | Article |
| id | doaj.art-8b7bc9c1b9ad448f8ac05f9ec709d075 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T07:51:24Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8b7bc9c1b9ad448f8ac05f9ec709d0752022-12-22T03:41:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.942417942417The synovial fluid fibroblast-like synoviocyte: A long-neglected piece in the puzzle of rheumatoid arthritis pathogenesisDorra Elhaj Mahmoud0Dorra Elhaj Mahmoud1Wajih Kaabachi2Nadia Sassi3Lamjed Tarhouni4Sonia Rekik5Samia Jemmali6Hela Sehli7Maryam Kallel-Sellami8Elhem Cheour9Lilia Laadhar10Immuno-Rheumatology Research Laboratory, Rheumatology Department, La Rabta Hospital, University of Tunis-El Manar, Tunis, TunisiaUnité de Recherche Infections Respiratoires Fongiques (IRF), Structure Fédérative de Recherche “Interactions Cellulaires et Applications Thérapeutiques” (SFR ICAT), Université d’Angers, Angers, FranceImmuno-Rheumatology Research Laboratory, Rheumatology Department, La Rabta Hospital, University of Tunis-El Manar, Tunis, TunisiaImmuno-Rheumatology Research Laboratory, Rheumatology Department, La Rabta Hospital, University of Tunis-El Manar, Tunis, TunisiaDepartment of Hand and Reconstructive Surgery, Kassab Institute of Traumatic and Orthopedic Surgery, Tunis, TunisiaImmuno-Rheumatology Research Laboratory, Rheumatology Department, La Rabta Hospital, University of Tunis-El Manar, Tunis, TunisiaImmuno-Rheumatology Research Laboratory, Rheumatology Department, La Rabta Hospital, University of Tunis-El Manar, Tunis, TunisiaImmuno-Rheumatology Research Laboratory, Rheumatology Department, La Rabta Hospital, University of Tunis-El Manar, Tunis, TunisiaImmuno-Rheumatology Research Laboratory, Rheumatology Department, La Rabta Hospital, University of Tunis-El Manar, Tunis, TunisiaImmuno-Rheumatology Research Laboratory, Rheumatology Department, La Rabta Hospital, University of Tunis-El Manar, Tunis, TunisiaImmuno-Rheumatology Research Laboratory, Rheumatology Department, La Rabta Hospital, University of Tunis-El Manar, Tunis, TunisiaRheumatoid arthritis (RA) is a systemic autoimmune disease during which fibroblast-like synoviocytes (FLS) contribute to both joint inflammation and destruction. FLS represent the core component of the synovial membrane. Following inflammation of this membrane, an effusion of cell-rich synovial fluid (SF) fills the joint cavity. Unlikely, SF has been shown to contain fibroblasts with some shared phenotypic traits with the synovial membrane FLS. These cells are called SF-FLS and their origin is still unclear. They are either brought into the synovium via migration through blood vessels, or they could originate within the synovium and exist in projections of the synovial membrane. SF-FLS function and phenotype are poorly documented compared to recently well-characterized synovial membrane FLS subsets. Furthermore, no study has yet reported a SF-FLS single-cell profiling analysis. This review will discuss the origin and cellular characteristics of SF-FLS in patients with RA. In addition, recent advances on the involvement of SF-FLS in the pathogenesis of RA will be summarized. Current knowledge on possible relationships between SF-FLS and other types of fibroblasts, including synovial membrane FLS, circulating fibrocytes, and pre- inflammatory mesenchymal (PRIME) cells will also be addressed. Finally, recent therapeutic strategies employed to specifically target SF-FLS in RA will be discussed.https://www.frontiersin.org/articles/10.3389/fimmu.2022.942417/fullrheumatoid arthritissynovial fluidfibroblast-like synoviocyteinflammationPRIME cellsfibrocyte |
| spellingShingle | Dorra Elhaj Mahmoud Dorra Elhaj Mahmoud Wajih Kaabachi Nadia Sassi Lamjed Tarhouni Sonia Rekik Samia Jemmali Hela Sehli Maryam Kallel-Sellami Elhem Cheour Lilia Laadhar The synovial fluid fibroblast-like synoviocyte: A long-neglected piece in the puzzle of rheumatoid arthritis pathogenesis Frontiers in Immunology rheumatoid arthritis synovial fluid fibroblast-like synoviocyte inflammation PRIME cells fibrocyte |
| title | The synovial fluid fibroblast-like synoviocyte: A long-neglected piece in the puzzle of rheumatoid arthritis pathogenesis |
| title_full | The synovial fluid fibroblast-like synoviocyte: A long-neglected piece in the puzzle of rheumatoid arthritis pathogenesis |
| title_fullStr | The synovial fluid fibroblast-like synoviocyte: A long-neglected piece in the puzzle of rheumatoid arthritis pathogenesis |
| title_full_unstemmed | The synovial fluid fibroblast-like synoviocyte: A long-neglected piece in the puzzle of rheumatoid arthritis pathogenesis |
| title_short | The synovial fluid fibroblast-like synoviocyte: A long-neglected piece in the puzzle of rheumatoid arthritis pathogenesis |
| title_sort | synovial fluid fibroblast like synoviocyte a long neglected piece in the puzzle of rheumatoid arthritis pathogenesis |
| topic | rheumatoid arthritis synovial fluid fibroblast-like synoviocyte inflammation PRIME cells fibrocyte |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.942417/full |
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