HECTD3 inhibits NLRP3 inflammasome assembly and activation by blocking NLRP3-NEK7 interaction

HECTD3 inhibits NLRP3 inflammasome assembly and activation by blocking NLRP3-NEK7 interaction

Abstract The NLRP3 inflammasome plays an important role in protecting the host from infection and aseptic inflammation, and its regulatory mechanism is not completely understood. Dysregulation of NLRP3 can cause diverse inflammatory diseases. HECTD3 is a E3 ubiquitin ligase of the HECT family that h...

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Bibliographic Details
Main Authors: Zhuo Cheng, Maobo Huang, Wei Li, Lei Hou, Li Jin, Qijin Fan, Linqiang Zhang, Chengbin Li, Li Zeng, Chuanyu Yang, Bin Liang, Fubing Li, Ceshi Chen
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06473-4

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https://doi.org/10.1038/s41419-024-06473-4

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