Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody

Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody

Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer. We describe the generation and selection of a potent antagonistic C5aR...

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Bibliographic Details
Main Authors: Leon Cyranka, Ida Mariegaard, Mikkel-Ole Skjødt, Rafael Bayarri-Olmos, Tom Eirik Mollnes, Peter Garred, Anne Rosbjerg
Format: Article
Language:English
Published: Karger Publishers 2023-11-01
Series:Journal of Innate Immunity
Subjects:
complement system
c5ar1
c5a
inflammation
monoclonal antibody
Online Access:https://beta.karger.com/Article/FullText/535084

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