Metagenomics-based systematic analysis reveals that gut microbiota Gd-IgA1-associated enzymes may play a key role in IgA nephropathy

Metagenomics-based systematic analysis reveals that gut microbiota Gd-IgA1-associated enzymes may play a key role in IgA nephropathy

Background: IgA nephropathy (IgAN) is the most common type of glomerulonephritis in Asia. Its pathogenesis involves higher expression of galactose-deficient IgA1 (Gd-IgA1) and dysregulated intestinal mucosal immunity. The objective of this study was to explore whether specific gut microbiota and ass...

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Bibliographic Details
Main Authors: Xiaolin Liang, Simeng Zhang, Difei Zhang, Liang Hu, La Zhang, Yu Peng, Yuan Xu, Haijing Hou, Chuan Zou, Xusheng Liu, Yang Chen, Fuhua Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
immunoglobulin a nephropathy
gut microbiota
galactose-deficient IgA1
Flavonifractor plautii
α-galactosidase
α-N-acetyl-galactosaminidase
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.970723/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2022.970723/full

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