Metagenomics-based systematic analysis reveals that gut microbiota Gd-IgA1-associated enzymes may play a key role in IgA nephropathy

Metagenomics-based systematic analysis reveals that gut microbiota Gd-IgA1-associated enzymes may play a key role in IgA nephropathy

Background: IgA nephropathy (IgAN) is the most common type of glomerulonephritis in Asia. Its pathogenesis involves higher expression of galactose-deficient IgA1 (Gd-IgA1) and dysregulated intestinal mucosal immunity. The objective of this study was to explore whether specific gut microbiota and ass...

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Bibliographic Details
Main Authors:	Xiaolin Liang, Simeng Zhang, Difei Zhang, Liang Hu, La Zhang, Yu Peng, Yuan Xu, Haijing Hou, Chuan Zou, Xusheng Liu, Yang Chen, Fuhua Lu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Series:	Frontiers in Molecular Biosciences
Subjects:	immunoglobulin a nephropathy gut microbiota galactose-deficient IgA1 Flavonifractor plautii α-galactosidase α-N-acetyl-galactosaminidase
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.970723/full

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