Natural Tr1-like cells do not confer long-term tolerogenic memory

IL-10-producing Tr1 cells promote tolerance but their contributions to tolerogenic memory are unclear. Using 10BiT mice that carry a Foxp3-eGFP reporter and stably express CD90.1 following IL-10 production, we characterized the spatiotemporal dynamics of Tr1 cells in a house dust mite model of aller...

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Bibliographic Details
Main Authors: Koshika Yadava, Carlos Obed Medina, Heather Ishak, Irina Gurevich, Hedwich Kuipers, Elya Ali Shamskhou, Ievgen O Koliesnik, James J Moon, Casey Weaver, Kari Christine Nadeau, Paul L Bollyky
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/44821