WBP2 restrains the lysosomal degradation of GPX4 to inhibit ferroptosis in cisplatin-induced acute kidney injury

WBP2 restrains the lysosomal degradation of GPX4 to inhibit ferroptosis in cisplatin-induced acute kidney injury

Cisplatin is one of the major causes of acute kidney injury (AKI) in clinical practice, and ferroptosis is an essential form of cell death in cisplatin-induced AKI (CP-AKI). WW domain binding protein-2 (WBP2), a molecular chaperon, is involved in the progression of various malignancies, but its role...

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Bibliographic Details
Main Authors: Zebin Deng, Yilong Wang, Jiachen Liu, Hao Zhang, Lizhi Zhou, Hao Zhao, Yachun Han, Shu Yan, Zheng Dong, Yinhuai Wang, Yingbo Dai, Fei Deng
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Redox Biology
Subjects:
WBP2
GPX4
Ferroptosis
Cisplatin
Acute kidney injury
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723002276

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http://www.sciencedirect.com/science/article/pii/S2213231723002276

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