Fetal Loss in Pregnant Rabbits Infected with Genotype 3 Hepatitis E Virus Is Associated with Altered Inflammatory Responses, Enhanced Virus Replication, and Extrahepatic Virus Dissemination with Positive Correlations with Increased Estradiol Level

Fetal Loss in Pregnant Rabbits Infected with Genotype 3 Hepatitis E Virus Is Associated with Altered Inflammatory Responses, Enhanced Virus Replication, and Extrahepatic Virus Dissemination with Positive Correlations with Increased Estradiol Level

ABSTRACT Hepatitis E virus (HEV) causes adverse clinical outcomes in pregnant women, but the underlying mechanisms remain poorly understood. To delineate the mechanisms of pregnancy-associated adverse effects during HEV infection, we utilized a genotype 3 HEV from rabbit (HEV-3ra) and its cognate ho...

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Bibliographic Details
Main Authors: Hassan M. Mahsoub, C. Lynn Heffron, Anna M. Hassebroek, Harini Sooryanarain, Bo Wang, Tanya LeRoith, Guillermo Raimundi Rodríguez, Debin Tian, Xiang-Jin Meng
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mBio
Subjects:
hepatitis E virus (HEV)
genotype 3 HEV
rabbit HEV
estradiol
pregnancy
fetal loss
Online Access:https://journals.asm.org/doi/10.1128/mbio.00418-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00418-23

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