Suppression of FOXM1 sensitizes human cancer cells to cell death induced by DNA-damage.

Suppression of FOXM1 sensitizes human cancer cells to cell death induced by DNA-damage.

Irradiation and DNA-damaging chemotherapeutic agents are commonly used in anticancer treatments. Following DNA damage FOXM1 protein levels are often elevated. In this study, we sought to investigate the potential role of FOXM1 in programmed cell death induced by DNA-damage. Human cancer cells after...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Marianna Halasi, Andrei L Gartel
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	Public Library of Science (PLoS) 2012-01-01
Cyfres:	PLoS ONE
Mynediad Ar-lein:	http://europepmc.org/articles/PMC3290538?pdf=render

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ShaPINg cell fate upon DNA damage:role of Pin1 isomerase in DNA damage-induced cell death and repair
gan: Thomas G Hofmann, et al.
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Recovery from a DNA-damage-induced G2 arrest requires Cdk-dependent activation of FoxM1.
gan: Alvarez-Fernández, M, et al.
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Engineered extracellular vesicles mediated CRISPR-induced deficiency of IQGAP1/FOXM1 reverses sorafenib resistance in HCC by suppressing cancer stem cells
gan: Cong He, et al.
Cyhoeddwyd: (2023-05-01)

Vitamin C suppresses cell death in MCF-7 human breast cancer cells induced by tamoxifen
gan: Subramani, Tamilselvan, et al.
Cyhoeddwyd: (2014)

Aspergillus Carneus metabolite Averufanin induced cell cycle arrest and apoptotic cell death on cancer cell lines via inducing DNA damage
gan: Deren Demirel, et al.
Cyhoeddwyd: (2023-04-01)

RNF112-mediated FOXM1 ubiquitination suppresses the proliferation and invasion of gastric cancer
gan: Shengwei Zhang, et al.
Cyhoeddwyd: (2023-06-01)

FOXM1 modulates cisplatin sensitivity by regulating EXO1 in ovarian cancer.
gan: Jinhua Zhou, et al.
Cyhoeddwyd: (2014-01-01)

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gan: Andy King Yin Lam, et al.
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gan: Joan Manils, et al.
Cyhoeddwyd: (2022-07-01)

Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells
gan: Semmes O John, et al.
Cyhoeddwyd: (2006-05-01)

Bersaldegenin-1,3,5-orthoacetate induces caspase-independent cell death, DNA damage and cell cycle arrest in human cervical cancer HeLa cells
gan: Justyna Stefanowicz-Hajduk, et al.
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gan: Damiano Conte, et al.
Cyhoeddwyd: (2012-01-01)

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gan: Smirnov, A, et al.
Cyhoeddwyd: (2016)

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gan: Zhu X, et al.
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Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes
gan: Philpott Michael P, et al.
Cyhoeddwyd: (2010-02-01)

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gan: Jason KH Lai, et al.
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gan: Cui Jun, et al.
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