Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury

Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury

Abstract Background The opening of pannexin1 channels is considered as a key event in inflammation. Pannexin1 channel-mediated release of adenosine triphosphate triggers inflammasome signaling and activation of immune cells. By doing so, pannexin1 channels play an important role in several inflammat...

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Bibliographic Details
Main Authors: Raf Van Campenhout, Timo W. M. De Groof, Prashant Kadam, Brenda R. Kwak, Serge Muyldermans, Nick Devoogdt, Mathieu Vinken
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Nanobiotechnology
Subjects:
Acute liver disease
Inflammation
Nanobody
Pannexin1
Therapy
Online Access:https://doi.org/10.1186/s12951-023-02137-1

Internet

https://doi.org/10.1186/s12951-023-02137-1

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