Design, Synthesis, and Biological Evaluation of Novel Phenoxy Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio-Pharmacological Inquiry, Histopathological Profiling, and Toxicological Scrutiny

Design, Synthesis, and Biological Evaluation of Novel Phenoxy Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio-Pharmacological Inquiry, Histopathological Profiling, and Toxicological Scrutiny

COX-2 plays a key role in converting arachidonic acid into prostaglandins. This makes it a significant target for treating inflammation. Selective COX-2 inhibitors have marked a new phase in inflammatory treatment, providing significant effectiveness while reducing negative side effects. Herein, we...

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Bibliographic Details
Main Authors: Najla A. Alshaye, Mohamed K. Elgohary, Mahmoud S. Elkotamy, Hatem A. Abdel-Aziz
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Molecules
Subjects:
anti-inflammatory
COX-1/COX-2
paw edema model
PGE-2
ulcerogenic effects
Online Access:https://www.mdpi.com/1420-3049/29/6/1309

Internet

https://www.mdpi.com/1420-3049/29/6/1309

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