HIF-1α inhibition ameliorates neonatal brain injury in a rat pup hypoxic–ischemic model

Hypoxia-inducible factor-1alpha (HIF-1α) has been considered as a regulator of both prosurvival and prodeath pathways in the nervous system. The present study was designed to elucidate the role of HIF-1α in neonatal hypoxic–ischemic (HI) brain injury. Rice–Vannucci model of neonatal hypoxic–ischemic...

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Bibliographic Details
Main Authors: Wanqiu Chen, Vikram Jadhav, Jiping Tang, John H. Zhang
Format: Article
Language:English
Published: Elsevier 2008-09-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108001241