Multidimensional fragmentomic profiling of cell-free DNA released from patient-derived organoids

Multidimensional fragmentomic profiling of cell-free DNA released from patient-derived organoids

Abstract Background Fragmentomics, the investigation of fragmentation patterns of cell-free DNA (cfDNA), has emerged as a promising strategy for the early detection of multiple cancers in the field of liquid biopsy. However, the clinical application of this approach has been hindered by a limited un...

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Bibliographic Details
Main Authors: Jaeryuk Kim, Seung-Pyo Hong, Seyoon Lee, Woochan Lee, Dakyung Lee, Rokhyun Kim, Young Jun Park, Sungji Moon, Kyunghyuk Park, Bukyoung Cha, Jong-Il Kim
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Human Genomics
Subjects:
Cell-free DNA biology
In vitro models
Fragmentomics
Organoids
Extrachromosomal circular DNA
Online Access:https://doi.org/10.1186/s40246-023-00533-0

Internet

https://doi.org/10.1186/s40246-023-00533-0

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