Inferring Homologous Recombination Deficiency of Ovarian Cancer From the Landscape of Copy Number Variation at Subchromosomal and Genetic Resolutions

Inferring Homologous Recombination Deficiency of Ovarian Cancer From the Landscape of Copy Number Variation at Subchromosomal and Genetic Resolutions

BackgroundHomologous recombination deficiency (HRD) is characterized by overall genomic instability and has emerged as an indispensable therapeutic target across various tumor types, particularly in ovarian cancer (OV). Unfortunately, current detection assays are far from perfect for identifying eve...

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Bibliographic Details
Main Authors: Meng Zhang, Si-Cong Ma, Jia-Le Tan, Jian Wang, Xue Bai, Zhong-Yi Dong, Qing-Xue Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Oncology
Subjects:
homologous recombination deficiency
copy number variation
ovarian cancer
biomarker
chromosome
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.772604/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.772604/full

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