Upregulation of CYP 450s expression of immortalized hepatocyte-like cells derived from mesenchymal stem cells by enzyme inducers

Upregulation of CYP 450s expression of immortalized hepatocyte-like cells derived from mesenchymal stem cells by enzyme inducers

<p>Abstract</p> <p>Background</p> <p>The strenuous procurement of cultured human hepatocytes and their short lives have constrained the cell culture model of cytochrome P450 (CYP450) induction, xenobiotic biotransformation, and hepatotoxicity. The development of continu...

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Bibliographic Details
Main Authors: Limsrichamrern Somchai, Akarasereenont Pravit, Borwornpinyo Suparerk, Nuntakarn Lalana, Duangsa-ard Sunisa, Kasetsinsombat Kanda, Wongkajornsilp Adisak, Sa-ngiamsuntorn Khanit, Hongeng Suradej
Format: Article
Language:English
Published: BMC 2011-09-01
Series:BMC Biotechnology
Subjects:
hepatocyte-like cell
immortalization
CYP450
MSC
Online Access:http://www.biomedcentral.com/1472-6750/11/89

Internet

http://www.biomedcentral.com/1472-6750/11/89

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