Irisin reduces bone fracture by facilitating osteogenesis and antagonizing TGF-β/Smad signaling in a growing mouse model of osteogenesis imperfecta

Irisin reduces bone fracture by facilitating osteogenesis and antagonizing TGF-β/Smad signaling in a growing mouse model of osteogenesis imperfecta

Objective: Osteogenesis imperfecta (OI) is a congenital disorder characterized by muscle defect and skeletal fragility, and no cure is yet available. Crosstalk between bone and muscle has become a new coming focus of therapeutic strategy in OI. Irisin, a secreted myokine, was found to be involved in...

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Bibliographic Details
Main Authors: Bin Sun, Huiqiao Wu, Jiajia Lu, Rongcheng Zhang, Xiaolong Shen, Yifei Gu, Changgui Shi, Ying Zhang, Wen Yuan
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Journal of Orthopaedic Translation
Subjects:
Irisin
TGF-β
Bone fracture
Osteogenesis imperfecta
Osteogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X22001176

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http://www.sciencedirect.com/science/article/pii/S2214031X22001176

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