Exploring the neuroprotective potential of Nrf2-pathway activators against annonacin toxicity

Abstract Modulation of the Nrf2 pathway, a master regulator of the antioxidant response and cellular metabolism, has been suggested as a promising therapeutic strategy in tauopathies, a heterogeneous group of neurodegenerative disorders characterized by intracellular proteinaceous inclusions of abno...

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Bibliographic Details
Main Authors: Márcia F. D. Costa, Thomas W. Rösler, Günter U. Höglinger
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-70837-1