CurQ+, a Next-Generation Formulation of Curcumin, Ameliorates Growth Plate Chondrocyte Stress and Increases Limb Growth in a Mouse Model of Pseudoachondroplasia

CurQ+, a Next-Generation Formulation of Curcumin, Ameliorates Growth Plate Chondrocyte Stress and Increases Limb Growth in a Mouse Model of Pseudoachondroplasia

Mutations in cartilage oligomeric matrix protein (COMP) causes protein misfolding and accumulation in chondrocytes that compromises skeletal growth and joint health in pseudoachondroplasia (PSACH), a severe dwarfing condition. Using the MT-COMP mice, a murine model of PSACH, we showed that pathologi...

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Bibliographic Details
Main Authors: Jacqueline T. Hecht, Alka C. Veerisetty, Mohammad G. Hossain, Frankie Chiu, Karen L. Posey
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
cartilage oligomeric matrix protein
COMP
autophagy
curcumin
dwarfism
chondrocyte
Online Access:https://www.mdpi.com/1422-0067/24/4/3845

Internet

https://www.mdpi.com/1422-0067/24/4/3845

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