Gravity-Vector Induces Mechanical Remodeling of rMSCs via Combined Substrate Stiffness and Orientation

Gravity-Vector Induces Mechanical Remodeling of rMSCs via Combined Substrate Stiffness and Orientation

Distinct physical factors originating from the cellular microenvironment are crucial to the biological homeostasis of stem cells. While substrate stiffness and orientation are known to regulate the mechanical remodeling and fate decision of mesenchymal stem cells (MSCs) separately, it remains unclea...

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Bibliographic Details
Main Authors: Chen Zhang, Dongyuan Lü, Fan Zhang, Yi Wu, Lu Zheng, Xiaoyu Zhang, Zhan Li, Shujin Sun, Mian Long
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
substrate stiffness
orientation
mechanosensing
nucleus translocation
cytoskeletal remodeling
focal adhesion complex reorganization
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.724101/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.724101/full

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