Saikosaponin A Inhibits Triple-Negative Breast Cancer Growth and Metastasis Through Downregulation of CXCR4

Saikosaponin A Inhibits Triple-Negative Breast Cancer Growth and Metastasis Through Downregulation of CXCR4

Purpose: Due to a lack of recognized molecular targets for therapy, patients with triple-negative breast cancer (TNBC), unlike other subtypes of breast cancers, generally have not benefited from the advances made with targeted agents. The CXCR4/SDF-1 axis is involved in tumor growth and metastasis o...

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Bibliographic Details
Main Authors: Ying Wang, Liang Zhao, Xianghui Han, Yahui Wang, Jinxia Mi, Changhong Wang, Duxin Sun, Yunfei Fu, Xiaodong Zhao, Haidong Guo, Qiangli Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Oncology
Subjects:
saikosaponin A
natural product
triple-negative breast cancer
metastasis
SDF-1/CXCR4 axis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01487/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01487/full

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