The anti-sigma factor MucA of Pseudomonas aeruginosa: Dramatic differences of a mucA22 vs. a ΔmucA mutant in anaerobic acidified nitrite sensitivity of planktonic and biofilm bacteria in vitro and during chronic murine lung infection.

The anti-sigma factor MucA of Pseudomonas aeruginosa: Dramatic differences of a mucA22 vs. a ΔmucA mutant in anaerobic acidified nitrite sensitivity of planktonic and biofilm bacteria in vitro and during chronic murine lung infection.

Mucoid mucA22 Pseudomonas aeruginosa (PA) is an opportunistic lung pathogen of cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) patients that is highly sensitive to acidified nitrite (A-NO2-). In this study, we first screened PA mutant strains for sensitivity or resistance to 20...

Full description

Bibliographic Details
Main Authors: Warunya Panmanee, Shengchang Su, Michael J Schurr, Gee W Lau, Xiaoting Zhu, Zhaowei Ren, Cameron T McDaniel, Long J Lu, Dennis E Ohman, Daniel A Muruve, Ralph J Panos, Hongwei D Yu, Thomas B Thompson, Boo Shan Tseng, Daniel J Hassett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0216401

Internet

https://doi.org/10.1371/journal.pone.0216401

Similar Items