The Pro-Inflammatory Deletion Allele of the NF-κB1 Polymorphism Is Characterized by a Depletion of Subunit p50 in Sepsis

The Pro-Inflammatory Deletion Allele of the NF-κB1 Polymorphism Is Characterized by a Depletion of Subunit p50 in Sepsis

The functionally important NF-κB1 promoter polymorphism (−94ins/delATTG) significantly shapes inflammation and impacts the outcome of sepsis. However, exploratory studies elucidating the molecular link of this genotype-dependent pattern are lacking. Accordingly, we analyzed lipopolysaccharide-stimul...

Full description

Bibliographic Details
Main Authors: Britta Marko, Paulina Heurich, Patrick Thon, Frieda Zimmer, Lars Bergmann, Hartmuth Nowak, Katharina Rump, Björn Koos, Michael Adamzik, Matthias Unterberg, Tim Rahmel
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells
NF-κB
NF-κB1 promoter polymorphism
subunit p50
sepsis
mitochondrial dysfunction
Online Access:https://www.mdpi.com/1422-0067/23/14/7559

Internet

https://www.mdpi.com/1422-0067/23/14/7559

Similar Items