The Impact of Protein Supplementation on Exercise-Induced Muscle Damage, Soreness and Fatigue Following Prolonged Walking Exercise in Vital Older Adults: A Randomized Double-Blind Placebo-Controlled Trial
Background: It is unknown whether protein supplementation can enhance recovery of exercise-induced muscle damage in older adults who have a disturbed muscle protein synthetic response. We assessed whether protein supplementation could attenuate exercise-induced muscle damage and soreness after prolo...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-06-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/12/6/1806 |
| _version_ | 1797565028214243328 |
|---|---|
| author | Dominique S. M. ten Haaf Coen C. W. G. Bongers Hugo G. Hulshof Thijs M. H. Eijsvogels Maria T. E. Hopman |
| author_facet | Dominique S. M. ten Haaf Coen C. W. G. Bongers Hugo G. Hulshof Thijs M. H. Eijsvogels Maria T. E. Hopman |
| author_sort | Dominique S. M. ten Haaf |
| collection | DOAJ |
| description | Background: It is unknown whether protein supplementation can enhance recovery of exercise-induced muscle damage in older adults who have a disturbed muscle protein synthetic response. We assessed whether protein supplementation could attenuate exercise-induced muscle damage and soreness after prolonged moderate-intensity walking exercise in older adults. Methods: In a double-blind, placebo-controlled intervention study, 104 subjects (81% male, ≥65 years) used either a protein (n = 50) or placebo supplement (n = 54) during breakfast and directly after exercise. Within a walking event, study subjects walked 30/40/50 km per day on three consecutive days. Muscle soreness and fatigue were determined with a numeric rating scale, and creatine kinase (CK) concentrations and serum inflammation markers were obtained. Results: Habitual protein intake was comparable between the protein (0.92 ± 0.27 g/kg/d) and placebo group (0.97 ± 0.23 g/kg/d, <i>p</i> = 0.31). At baseline, comparable CK concentrations were found between the protein and the placebo group (110 (IQR: 84–160 U/L) and 115 (IQR: 91–186 U/L), respectively, <i>p</i> = 0.84). Prolonged walking (protein: 32 ± 9 km/d, placebo: 33 ± 6 km/d) resulted in a cumulative increase of CK in both the protein (∆283 (IQR: 182–662 U/L)) and placebo group (∆456 (IQR: 209–885 U/L)) after three days. CK elevations were not significantly different between groups (<i>p</i> = 0.43). Similarly, no differences in inflammation markers, muscle soreness and fatigue were found between groups. Conclusions: Protein supplementation does not attenuate exercise-induced muscle damage, muscle soreness or fatigue in older adults performing prolonged moderate-intensity walking exercise. |
| first_indexed | 2024-03-10T19:06:14Z |
| format | Article |
| id | doaj.art-8bab49da879e426ba95c5b81d61e9824 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T19:06:14Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-8bab49da879e426ba95c5b81d61e98242023-11-20T04:07:16ZengMDPI AGNutrients2072-66432020-06-01126180610.3390/nu12061806The Impact of Protein Supplementation on Exercise-Induced Muscle Damage, Soreness and Fatigue Following Prolonged Walking Exercise in Vital Older Adults: A Randomized Double-Blind Placebo-Controlled TrialDominique S. M. ten Haaf0Coen C. W. G. Bongers1Hugo G. Hulshof2Thijs M. H. Eijsvogels3Maria T. E. Hopman4Radboud Institute for Health Sciences, Department of Physiology, Radboud University Medical Center, 6500 HB Nijmegen, The NetherlandsRadboud Institute for Health Sciences, Department of Physiology, Radboud University Medical Center, 6500 HB Nijmegen, The NetherlandsRadboud Institute for Health Sciences, Department of Physiology, Radboud University Medical Center, 6500 HB Nijmegen, The NetherlandsRadboud Institute for Health Sciences, Department of Physiology, Radboud University Medical Center, 6500 HB Nijmegen, The NetherlandsRadboud Institute for Health Sciences, Department of Physiology, Radboud University Medical Center, 6500 HB Nijmegen, The NetherlandsBackground: It is unknown whether protein supplementation can enhance recovery of exercise-induced muscle damage in older adults who have a disturbed muscle protein synthetic response. We assessed whether protein supplementation could attenuate exercise-induced muscle damage and soreness after prolonged moderate-intensity walking exercise in older adults. Methods: In a double-blind, placebo-controlled intervention study, 104 subjects (81% male, ≥65 years) used either a protein (n = 50) or placebo supplement (n = 54) during breakfast and directly after exercise. Within a walking event, study subjects walked 30/40/50 km per day on three consecutive days. Muscle soreness and fatigue were determined with a numeric rating scale, and creatine kinase (CK) concentrations and serum inflammation markers were obtained. Results: Habitual protein intake was comparable between the protein (0.92 ± 0.27 g/kg/d) and placebo group (0.97 ± 0.23 g/kg/d, <i>p</i> = 0.31). At baseline, comparable CK concentrations were found between the protein and the placebo group (110 (IQR: 84–160 U/L) and 115 (IQR: 91–186 U/L), respectively, <i>p</i> = 0.84). Prolonged walking (protein: 32 ± 9 km/d, placebo: 33 ± 6 km/d) resulted in a cumulative increase of CK in both the protein (∆283 (IQR: 182–662 U/L)) and placebo group (∆456 (IQR: 209–885 U/L)) after three days. CK elevations were not significantly different between groups (<i>p</i> = 0.43). Similarly, no differences in inflammation markers, muscle soreness and fatigue were found between groups. Conclusions: Protein supplementation does not attenuate exercise-induced muscle damage, muscle soreness or fatigue in older adults performing prolonged moderate-intensity walking exercise.https://www.mdpi.com/2072-6643/12/6/1806muscle damageelderlyphysical activityendurance exercisemilk protein concentrate |
| spellingShingle | Dominique S. M. ten Haaf Coen C. W. G. Bongers Hugo G. Hulshof Thijs M. H. Eijsvogels Maria T. E. Hopman The Impact of Protein Supplementation on Exercise-Induced Muscle Damage, Soreness and Fatigue Following Prolonged Walking Exercise in Vital Older Adults: A Randomized Double-Blind Placebo-Controlled Trial Nutrients muscle damage elderly physical activity endurance exercise milk protein concentrate |
| title | The Impact of Protein Supplementation on Exercise-Induced Muscle Damage, Soreness and Fatigue Following Prolonged Walking Exercise in Vital Older Adults: A Randomized Double-Blind Placebo-Controlled Trial |
| title_full | The Impact of Protein Supplementation on Exercise-Induced Muscle Damage, Soreness and Fatigue Following Prolonged Walking Exercise in Vital Older Adults: A Randomized Double-Blind Placebo-Controlled Trial |
| title_fullStr | The Impact of Protein Supplementation on Exercise-Induced Muscle Damage, Soreness and Fatigue Following Prolonged Walking Exercise in Vital Older Adults: A Randomized Double-Blind Placebo-Controlled Trial |
| title_full_unstemmed | The Impact of Protein Supplementation on Exercise-Induced Muscle Damage, Soreness and Fatigue Following Prolonged Walking Exercise in Vital Older Adults: A Randomized Double-Blind Placebo-Controlled Trial |
| title_short | The Impact of Protein Supplementation on Exercise-Induced Muscle Damage, Soreness and Fatigue Following Prolonged Walking Exercise in Vital Older Adults: A Randomized Double-Blind Placebo-Controlled Trial |
| title_sort | impact of protein supplementation on exercise induced muscle damage soreness and fatigue following prolonged walking exercise in vital older adults a randomized double blind placebo controlled trial |
| topic | muscle damage elderly physical activity endurance exercise milk protein concentrate |
| url | https://www.mdpi.com/2072-6643/12/6/1806 |
| work_keys_str_mv | AT dominiquesmtenhaaf theimpactofproteinsupplementationonexerciseinducedmuscledamagesorenessandfatiguefollowingprolongedwalkingexerciseinvitalolderadultsarandomizeddoubleblindplacebocontrolledtrial AT coencwgbongers theimpactofproteinsupplementationonexerciseinducedmuscledamagesorenessandfatiguefollowingprolongedwalkingexerciseinvitalolderadultsarandomizeddoubleblindplacebocontrolledtrial AT hugoghulshof theimpactofproteinsupplementationonexerciseinducedmuscledamagesorenessandfatiguefollowingprolongedwalkingexerciseinvitalolderadultsarandomizeddoubleblindplacebocontrolledtrial AT thijsmheijsvogels theimpactofproteinsupplementationonexerciseinducedmuscledamagesorenessandfatiguefollowingprolongedwalkingexerciseinvitalolderadultsarandomizeddoubleblindplacebocontrolledtrial AT mariatehopman theimpactofproteinsupplementationonexerciseinducedmuscledamagesorenessandfatiguefollowingprolongedwalkingexerciseinvitalolderadultsarandomizeddoubleblindplacebocontrolledtrial AT dominiquesmtenhaaf impactofproteinsupplementationonexerciseinducedmuscledamagesorenessandfatiguefollowingprolongedwalkingexerciseinvitalolderadultsarandomizeddoubleblindplacebocontrolledtrial AT coencwgbongers impactofproteinsupplementationonexerciseinducedmuscledamagesorenessandfatiguefollowingprolongedwalkingexerciseinvitalolderadultsarandomizeddoubleblindplacebocontrolledtrial AT hugoghulshof impactofproteinsupplementationonexerciseinducedmuscledamagesorenessandfatiguefollowingprolongedwalkingexerciseinvitalolderadultsarandomizeddoubleblindplacebocontrolledtrial AT thijsmheijsvogels impactofproteinsupplementationonexerciseinducedmuscledamagesorenessandfatiguefollowingprolongedwalkingexerciseinvitalolderadultsarandomizeddoubleblindplacebocontrolledtrial AT mariatehopman impactofproteinsupplementationonexerciseinducedmuscledamagesorenessandfatiguefollowingprolongedwalkingexerciseinvitalolderadultsarandomizeddoubleblindplacebocontrolledtrial |