Nephroprotective Role of Combined Sitagliptin and Oleuropein in Cisplatin-Induced Acute Kidney Injury: Regulation of SDF-1α/Nrf2/ HO-1 Axis and Autophagy

Nephroprotective Role of Combined Sitagliptin and Oleuropein in Cisplatin-Induced Acute Kidney Injury: Regulation of SDF-1α/Nrf2/ HO-1 Axis and Autophagy

Background: Accumulating evidence proves that cisplatin, a widely used anticancer, causes acute kidney injury (AKI). Sitagliptin (Sita), a dipeptidyl peptidase-4 (DPP4) inhibitor, is a hypoglycemic agent that can promote tissue angiogenesis and cell survival. However, little is known about the nephr...

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Bibliographic Details
Main Authors: Mohamed Bassiony, Nesreen O Omar, Amira M Badr, Nadia M Hamdy, Eman F Sanad
Format: Article
Language:English
Published: Ain Shams University 2021-12-01
Series:Archives of Pharmaceutical Sciences Ain Shams University
Subjects:
cisplatin
acute kidney injury
sitagliptin
oleuropein
sdf-1α
nrf2
autophagy
caspase-3
Online Access:https://aps.journals.ekb.eg/article_232604.html

Internet

https://aps.journals.ekb.eg/article_232604.html

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