Chemotherapy-elicited exosomal miR-378a-3p and miR-378d promote breast cancer stemness and chemoresistance via the activation of EZH2/STAT3 signaling

Chemotherapy-elicited exosomal miR-378a-3p and miR-378d promote breast cancer stemness and chemoresistance via the activation of EZH2/STAT3 signaling

Abstract Background Not all breast cancer (BC) patients who receive neoadjuvant chemotherapy achieve a pathologic complete response (pCR), but the reasons for this are unknown. Previous studies have shown that exosomes produced in the tumor microenvironment in response to chemotherapy promote a chem...

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Bibliographic Details
Main Authors: Qianxi Yang, Shaorong Zhao, Zhendong Shi, Lixia Cao, Jingjing Liu, Teng Pan, Dongdong Zhou, Jin Zhang
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Chemotherapy-elicited exosomes
miR-378a-3p
miR-378d
Chemotherapy resistance
Cancer stemness
Online Access:https://doi.org/10.1186/s13046-021-01901-1

Internet

https://doi.org/10.1186/s13046-021-01901-1

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