PARP-inhibitor treatment prevents hypertension induced cardiac remodeling by favorable modulation of heat shock proteins, Akt-1/GSK-3β and several PKC isoforms.

PARP-inhibitor treatment prevents hypertension induced cardiac remodeling by favorable modulation of heat shock proteins, Akt-1/GSK-3β and several PKC isoforms.

Spontaneously hypertensive rat (SHR) is a suitable model for studies of the complications of hypertension. It is known that activation of poly(ADP-ribose) polymerase enzyme (PARP) plays an important role in the development of postinfarction as well as long-term hypertension induced heart failure. In...

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Bibliographic Details
Main Authors: Laszlo Deres, Eva Bartha, Anita Palfi, Krisztian Eros, Adam Riba, Janos Lantos, Tamas Kalai, Kalman Hideg, Balazs Sumegi, Ferenc Gallyas, Kalman Toth, Robert Halmosi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4094529?pdf=render

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http://europepmc.org/articles/PMC4094529?pdf=render

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