Primaquine–quinoxaline 1,4-di-N-oxide hybrids with action on the exo-erythrocytic forms of Plasmodium induce their effect by the production of reactive oxygen species

Primaquine–quinoxaline 1,4-di-N-oxide hybrids with action on the exo-erythrocytic forms of Plasmodium induce their effect by the production of reactive oxygen species

Abstract Background The challenge in anti-malarial chemotherapy is based on the emergence of resistance to drugs and the search for medicines against all stages of the life cycle of Plasmodium spp. as a therapeutic target. Nowadays, many molecules with anti-malarial activity are reported. However, f...

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Bibliographic Details
Main Authors: Leonardo Bonilla-Ramírez, Silvia Galiano, Miguel Quiliano, Ignacio Aldana, Adriana Pabón
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Malaria Journal
Subjects:
Malaria
Plasmodium
Exoerythrocytic stage
Quinoxaline 1
4-Di-N-oxide
Cell death
Online Access:http://link.springer.com/article/10.1186/s12936-019-2825-8

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http://link.springer.com/article/10.1186/s12936-019-2825-8

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