Virus host protein interaction network analysis reveals that the HEV ORF3 protein may interrupt the blood coagulation process.

Hepatitis E virus (HEV) is endemic worldwide and a major cause of acute liver disease in developing countries. However, the molecular mechanisms of liver pathology and clinical disease are not well understood for HEV infection. Open reading frame 3 (ORF3) of HEV encodes a small phosphoprotein, which...

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Bibliographic Details
Main Authors: Yansheng Geng, Jun Yang, Weijin Huang, Tim J Harrison, Yan Zhou, Zhiheng Wen, Youchun Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3571956?pdf=render