RAD51AP1 and RAD54L Can Underpin Two Distinct RAD51-Dependent Routes of DNA Damage Repair via Homologous Recombination

RAD51AP1 and RAD54L Can Underpin Two Distinct RAD51-Dependent Routes of DNA Damage Repair via Homologous Recombination

Homologous recombination DNA repair (HR) is a complex DNA damage repair pathway and an attractive target of inhibition in anti-cancer therapy. To help guide the development of efficient HR inhibitors, it is critical to identify compensatory HR sub-pathways. In this study, we describe a novel synthet...

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Bibliographic Details
Main Authors: Platon Selemenakis, Neelam Sharma, Mollie E. Uhrig, Jeffrey Katz, Youngho Kwon, Patrick Sung, Claudia Wiese
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
homologous recombination
replication
genome stability
genetic interaction
RAD51AP1
RAD54L
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.866601/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.866601/full

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