Whole-genome functional characterization of RE1 silencers using a modified massively parallel reporter assay

Whole-genome functional characterization of RE1 silencers using a modified massively parallel reporter assay

Summary: Both upregulation and downregulation by cis-regulatory elements help modulate precise gene expression. However, our understanding of repressive elements is far more limited than activating elements. To address this gap, we characterized RE1, a group of transcriptional silencers bound by RES...

Full description

Bibliographic Details
Main Authors: Kousuke Mouri, Hannah B. Dewey, Rodrigo Castro, Daniel Berenzy, Susan Kales, Ryan Tewhey
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cell Genomics
Subjects:
gene regulation
silencer
REST
RE1
transcription factor
MPRA
Online Access:http://www.sciencedirect.com/science/article/pii/S2666979X22001926

Internet

http://www.sciencedirect.com/science/article/pii/S2666979X22001926

Similar Items