Panobinostat enhances olaparib efficacy by modifying expression of homologous recombination repair and immune transcripts in ovarian cancer

Panobinostat enhances olaparib efficacy by modifying expression of homologous recombination repair and immune transcripts in ovarian cancer

Histone deacetylase inhibitors (HDACi) sensitize homologous recombination (HR)-proficient human ovarian cancer cells to PARP inhibitors (PARPi). To investigate mechanisms of anti-tumor effects of combined HDACi/PARPi treatment we performed transcriptome analysis in HR- proficient human ovarian cance...

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Detaylı Bibliyografya
Asıl Yazarlar: Andrew J. Wilson, Vijayalaxmi G Gupta, Qi Liu, Fiona Yull, Marta A. Crispens, Dineo Khabele
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Elsevier 2022-02-01
Seri Bilgileri:Neoplasia: An International Journal for Oncology Research
Konular:
Ovarian cancer
Histone deacetylase inhibitors
PARP inhibitors
Homologous recombination repair
Immune response
Online Erişim:http://www.sciencedirect.com/science/article/pii/S1476558621001068

Internet

http://www.sciencedirect.com/science/article/pii/S1476558621001068

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