Panobinostat enhances olaparib efficacy by modifying expression of homologous recombination repair and immune transcripts in ovarian cancer

Panobinostat enhances olaparib efficacy by modifying expression of homologous recombination repair and immune transcripts in ovarian cancer

Histone deacetylase inhibitors (HDACi) sensitize homologous recombination (HR)-proficient human ovarian cancer cells to PARP inhibitors (PARPi). To investigate mechanisms of anti-tumor effects of combined HDACi/PARPi treatment we performed transcriptome analysis in HR- proficient human ovarian cance...

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Bibliographic Details
Main Authors: Andrew J. Wilson, Vijayalaxmi G Gupta, Qi Liu, Fiona Yull, Marta A. Crispens, Dineo Khabele
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Ovarian cancer
Histone deacetylase inhibitors
PARP inhibitors
Homologous recombination repair
Immune response
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621001068

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http://www.sciencedirect.com/science/article/pii/S1476558621001068

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