Expression of selected genes isolated from whole blood, liver and obex in lambs with experimental classical scrapie and healthy controls, showing a systemic innate immune response at the clinical end-stage

Expression of selected genes isolated from whole blood, liver and obex in lambs with experimental classical scrapie and healthy controls, showing a systemic innate immune response at the clinical end-stage

Abstract Background Incubation period, disease progression, pathology and clinical presentation of classical scrapie in sheep are highly dependent on PRNP genotype, time and route of inoculation and prion strain. Our experimental model with pre-colostrum inoculation of homozygous VRQ lambs has shown...

Full description

Bibliographic Details
Main Authors: Siv Meling, Kerstin Skovgaard, Kjetil Bårdsen, Peter Mikael Helweg Heegaard, Martha J. Ulvund
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Veterinary Research
Subjects:
Classical scrapie
Innate immune response
qPCR
Whole blood
Liver tissue
Brain tissue
Online Access:http://link.springer.com/article/10.1186/s12917-018-1607-9

Internet

http://link.springer.com/article/10.1186/s12917-018-1607-9

Similar Items