An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo

An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo

Abstract Background Restraining or slowing ageing hallmarks at the cellular level have been proposed as a route to increased organismal lifespan and healthspan. Consequently, there is great interest in anti-ageing drug discovery. However, this currently requires laborious and lengthy longevity analy...

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Bibliographic Details
Main Authors: Celia Lujan, Eleanor Jane Tyler, Simone Ecker, Amy Philomena Webster, Eleanor Rachel Stead, Victoria Eugenia Martinez-Miguel, Deborah Milligan, James Charles Garbe, Martha Ruskin Stampfer, Stephan Beck, Robert Lowe, Cleo Lucinda Bishop, Ivana Bjedov
Format: Article
Language:English
Published: BMC 2024-07-01
Series:Genome Medicine
Subjects:
Senescence
CellPopAge epigenetic Clock
Drug discovery
Ageing
CpG methylation
Rapamycin
Online Access:https://doi.org/10.1186/s13073-024-01349-w

Internet

https://doi.org/10.1186/s13073-024-01349-w

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