Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in <named-content content-type="genus-species">Escherichia coli</named-content>

Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in <named-content content-type="genus-species">Escherichia coli</named-content>

ABSTRACT Although the TEM-1 β-lactamase (BlaTEM-1) hydrolyzes penicillins and narrow-spectrum cephalosporins, organisms expressing this enzyme are typically susceptible to β-lactam/β-lactamase inhibitor combinations such as piperacillin-tazobactam (TZP). However, our previous work led to the discove...

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Bibliographic Details
Main Authors: Lisa M. Schechter, David P. Creely, Cherilyn D. Garner, Dee Shortridge, Hoan Nguyen, Lei Chen, Blake M. Hanson, Erica Sodergren, George M. Weinstock, W. Michael Dunne, Alex van Belkum, Shana R. Leopold
Format: Article
Language:English
Published: American Society for Microbiology 2018-05-01
Series:mBio
Subjects:
Escherichia coli
TEM-1
antibiotic resistance
gene amplification
piperacillin-tazobactam
Online Access:https://journals.asm.org/doi/10.1128/mBio.00583-18

Internet

https://journals.asm.org/doi/10.1128/mBio.00583-18

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