Microglial SIRPα regulates the emergence of CD11c+ microglia and demyelination damage in white matter
A characteristic subset of microglia expressing CD11c appears in response to brain damage. However, the functional role of CD11c+ microglia, as well as the mechanism of its induction, are poorly understood. Here we report that the genetic ablation of signal regulatory protein α (SIRPα), a membrane p...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-03-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/42025 |