Natural spike trains trigger short- and long-lasting dynamics at hippocampal mossy fiber synapses in rodents.
Synapses exhibit strikingly different forms of plasticity over a wide range of time scales, from milliseconds to hours. Studies on synaptic plasticity typically use constant-frequency stimulation to activate synapses, whereas in vivo activity of neurons is irregular.Using extracellular and whole-cel...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2010-04-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2848597?pdf=render |
| _version_ | 1818527898933395456 |
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| author | Anja Gundlfinger Jörg Breustedt David Sullivan Dietmar Schmitz |
| author_facet | Anja Gundlfinger Jörg Breustedt David Sullivan Dietmar Schmitz |
| author_sort | Anja Gundlfinger |
| collection | DOAJ |
| description | Synapses exhibit strikingly different forms of plasticity over a wide range of time scales, from milliseconds to hours. Studies on synaptic plasticity typically use constant-frequency stimulation to activate synapses, whereas in vivo activity of neurons is irregular.Using extracellular and whole-cell electrophysiological recordings, we have here studied the synaptic responses at hippocampal mossy fiber synapses in vitro to stimulus patterns obtained from in vivo recordings of place cell firing of dentate gyrus granule cells in behaving rodents. We find that synaptic strength is strongly modulated on short- and long-lasting time scales during the presentation of the natural stimulus trains.We conclude that dynamic short- and long-term synaptic plasticity at the hippocampal mossy fiber synapse plays a prominent role in normal synaptic function. |
| first_indexed | 2024-12-11T06:42:27Z |
| format | Article |
| id | doaj.art-8bcb759f0fd8496388d82c39e579bf86 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T06:42:27Z |
| publishDate | 2010-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8bcb759f0fd8496388d82c39e579bf862022-12-22T01:17:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-04-0154e996110.1371/journal.pone.0009961Natural spike trains trigger short- and long-lasting dynamics at hippocampal mossy fiber synapses in rodents.Anja GundlfingerJörg BreustedtDavid SullivanDietmar SchmitzSynapses exhibit strikingly different forms of plasticity over a wide range of time scales, from milliseconds to hours. Studies on synaptic plasticity typically use constant-frequency stimulation to activate synapses, whereas in vivo activity of neurons is irregular.Using extracellular and whole-cell electrophysiological recordings, we have here studied the synaptic responses at hippocampal mossy fiber synapses in vitro to stimulus patterns obtained from in vivo recordings of place cell firing of dentate gyrus granule cells in behaving rodents. We find that synaptic strength is strongly modulated on short- and long-lasting time scales during the presentation of the natural stimulus trains.We conclude that dynamic short- and long-term synaptic plasticity at the hippocampal mossy fiber synapse plays a prominent role in normal synaptic function.http://europepmc.org/articles/PMC2848597?pdf=render |
| spellingShingle | Anja Gundlfinger Jörg Breustedt David Sullivan Dietmar Schmitz Natural spike trains trigger short- and long-lasting dynamics at hippocampal mossy fiber synapses in rodents. PLoS ONE |
| title | Natural spike trains trigger short- and long-lasting dynamics at hippocampal mossy fiber synapses in rodents. |
| title_full | Natural spike trains trigger short- and long-lasting dynamics at hippocampal mossy fiber synapses in rodents. |
| title_fullStr | Natural spike trains trigger short- and long-lasting dynamics at hippocampal mossy fiber synapses in rodents. |
| title_full_unstemmed | Natural spike trains trigger short- and long-lasting dynamics at hippocampal mossy fiber synapses in rodents. |
| title_short | Natural spike trains trigger short- and long-lasting dynamics at hippocampal mossy fiber synapses in rodents. |
| title_sort | natural spike trains trigger short and long lasting dynamics at hippocampal mossy fiber synapses in rodents |
| url | http://europepmc.org/articles/PMC2848597?pdf=render |
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