Doxycycline-Eluting Core-Shell Type Nanofiber-Covered Trachea Stent for Inhibition of Cellular Metalloproteinase and Its Related Fibrotic Stenosis

Doxycycline-Eluting Core-Shell Type Nanofiber-Covered Trachea Stent for Inhibition of Cellular Metalloproteinase and Its Related Fibrotic Stenosis

In this study, we fabricated a doxycycline (doxy)-eluting nanofiber-covered endotracheal stent for the prevention of stent intubation-related tissue fibrosis and re-stenosis. The nanofiber was deposited directly on the outer surface of the stent using a coaxial electrospinning method to form a doxy-...

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Bibliographic Details
Main Authors: Rengarajan Baskaran, Un-Jeong Ko, Enkhzaya Davaa, Ji Eun Park, Yixin Jiang, Junghan Lee, Su-Geun Yang
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Pharmaceutics
Subjects:
electrospinning
coaxial nanofiber
fibrosis
trachea stenosis
doxycycline
MMP
Online Access:https://www.mdpi.com/1999-4923/11/8/421

Internet

https://www.mdpi.com/1999-4923/11/8/421

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