Photodynamic Inactivation of Bacteria with Porphyrin Derivatives: Effect of Charge, Lipophilicity, ROS Generation, and Cellular Uptake on Their Biological Activity In Vitro

Photodynamic Inactivation of Bacteria with Porphyrin Derivatives: Effect of Charge, Lipophilicity, ROS Generation, and Cellular Uptake on Their Biological Activity In Vitro

Resistance of microorganisms to antibiotics has led to research on various therapeutic strategies with different mechanisms of action, including photodynamic inactivation (PDI). In this work, we evaluated a cationic, neutral, and anionic <i>meso</i>-tetraphenylporphyrin derivative’s abil...

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Bibliographic Details
Main Authors: Adam Sułek, Barbara Pucelik, Marcin Kobielusz, Agata Barzowska, Janusz M. Dąbrowski
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
antimicrobial activity
efflux pumps
multidrug resistance (MDR)
photodynamic inactivation (PDI)
porphyrins
reactive oxygen species (ROS)
Online Access:https://www.mdpi.com/1422-0067/21/22/8716

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https://www.mdpi.com/1422-0067/21/22/8716

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