The Hydrophobic Residues in Amino Terminal Domains of Cx46 and Cx50 Are Important for Their Gap Junction Channel Ion Permeation and Gating

The Hydrophobic Residues in Amino Terminal Domains of Cx46 and Cx50 Are Important for Their Gap Junction Channel Ion Permeation and Gating

Lens gap junctions (GJs) formed by Cx46 and Cx50 are important to keep lens transparency. Functional studies on Cx46 and Cx50 GJs showed that the V<sub>j</sub>-gating, single channel conductance (γ<sub>j</sub>), gating polarity, and/or channel open stability could be modified...

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Bibliographic Details
Main Authors: Roa’a Jaradat, Xiaole Li, Honghong Chen, Peter B. Stathopulos, Donglin Bai
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
gap junction structure
Cx46
Cx50
amino terminal domain
V<sub>j</sub>-gating
single channel conductance
Online Access:https://www.mdpi.com/1422-0067/23/19/11605

Internet

https://www.mdpi.com/1422-0067/23/19/11605

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