APOL1 renal risk variants exacerbate podocyte injury by increasing inflammatory stress

APOL1 renal risk variants exacerbate podocyte injury by increasing inflammatory stress

Abstract Background Apolipoprotein L1, APOL1, is a trypanosome lytic factor present in human and certain other primates. APOL1 gene variants, present in individuals of recent sub-Saharan African descent, increase risk for glomerular disease and associate with the disease progression, but the molecul...

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Bibliographic Details
Main Authors: Hidefumi Wakashin, Jurgen Heymann, Hila Roshanravan, Parnaz Daneshpajouhnejad, Avi Rosenberg, Myung Kyun Shin, Maarten Hoek, Jeffrey B. Kopp
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Nephrology
Subjects:
APOL1
Protein isoform
Interleukin-1 beta
NLRP12
Podocytes
Kidney
Online Access:http://link.springer.com/article/10.1186/s12882-020-01995-3

Internet

http://link.springer.com/article/10.1186/s12882-020-01995-3

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