Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils

Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils

Abstract Examination of early phases of synucleinopathy when inclusions are present, but long before neurodegeneration occurs, is critical to both understanding disease progression and the development of disease modifying therapies. The rat alpha-synuclein (α-syn) preformed fibril (PFF) model induce...

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Bibliographic Details
Main Authors: Joseph R. Patterson, Joseph Kochmanski, Anna C. Stoll, Michael Kubik, Christopher J. Kemp, Megan F. Duffy, Kajene Thompson, Jacob W. Howe, Allyson Cole-Strauss, Nathan C. Kuhn, Kathryn M. Miller, Seth Nelson, Christopher U. Onyekpe, John S. Beck, Scott E. Counts, Alison I. Bernstein, Kathy Steece-Collier, Kelvin C. Luk, Caryl E. Sortwell
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-023-00620-y

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https://doi.org/10.1038/s41531-023-00620-y

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