Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca2+ signalling

Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca2+ signalling

Abstract Background Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease that is embodied by the loss of salivary gland function and immune cell infiltration, but the mechanism(s) are still unknown. The aim of this study was to understand the mechanisms and identify key factors tha...

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Bibliographic Details
Main Authors: Yuyang Sun, Viviane Nascimento Da Conceicao, Arun Chauhan, Pramod Sukumaran, Pooja Chauhan, Julian L. Ambrus, Arjan Vissink, Frans G. M. Kroese, Madesh Muniswamy, Bibhuti B. Mishra, Brij B. Singh
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Clinical and Translational Medicine
Subjects:
alarmins
Ca2+ signalling
ER stress
immune cell activation
primary Sjogren's syndrome
salivary gland dysfunction
Online Access:https://doi.org/10.1002/ctm2.1228

Internet

https://doi.org/10.1002/ctm2.1228

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