Sfrp1 attenuates TAC-induced cardiac dysfunction by inhibiting Wnt signaling pathway- mediated myocardial apoptosis in mice

Sfrp1 attenuates TAC-induced cardiac dysfunction by inhibiting Wnt signaling pathway- mediated myocardial apoptosis in mice

Abstract Background Hemodynamic overload causes cardiac hypertrophy leading to heart failure. Wnt signaling pathway was reported activated in heart failure. Secreted frizzled related protein 1 (Sfrp1) is a suppressor of Wnt signaling activation. The aim of the present study was to investigate the pr...

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Bibliographic Details
Main Authors: Shuo Pan, Xiujuan Zhao, Xu Wang, Xin Tian, Yuanbo Wang, Rong Fan, Na Feng, Shumiao Zhang, Xiaoming Gu, Min Jia, Juan Li, Lu Yang, Kaiyan Wang, Haitao Guo, Jianming Pei
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Lipids in Health and Disease
Subjects:
Heart failure
Wnt signaling pathway
Sfrp1
Viral vector
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12944-018-0832-3

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http://link.springer.com/article/10.1186/s12944-018-0832-3

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