ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons

ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons

Many actin cytoskeleton-regulating proteins control dendritic spine morphology and density, which are cellular features often altered in autism spectrum disorder (ASD). Recent studies using animal models show that autism-related behavior can be rescued by either manipulating actin regulators or by r...

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Bibliographic Details
Main Authors: Iryna Hlushchenko, Pushpa Khanal, Amr Abouelezz, Ville O. Paavilainen, Pirta Hotulainen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
autism spectrum disorder
actin cytoskeleton
dendritic spines
inhibitory synapses
de novo point mutations
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00217/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00217/full

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