Modulation of Cardiac Autonomic Function by Fingolimod Initiation and Predictors for Fingolimod Induced Bradycardia in Patients with Multiple Sclerosis

Modulation of Cardiac Autonomic Function by Fingolimod Initiation and Predictors for Fingolimod Induced Bradycardia in Patients with Multiple Sclerosis

Objective: It is well-known that initiation of fingolimod induces a transient decrease of heart rate. However, the underlying cardiac autonomic regulation is poorly understood. We aimed to investigate the changes of autonomic activity caused by the first dose of fingolimod using a long-term multiple...

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Bibliographic Details
Main Authors: Kai Li, Urszula Konofalska, Katja Akgün, Manja Reimann, Heinz Rüdiger, Rocco Haase, Tjalf Ziemssen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Neuroscience
Subjects:
fingolimod
multiple sclerosis
cardiac autonomic function
multiple trigonometric regressive spectral analysis
bradycardia
heart rate variability (HRV)
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00540/full

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http://journal.frontiersin.org/article/10.3389/fnins.2017.00540/full

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