Oleanolic acid targets the regulation of PI3K/AKT/mTOR pathway and activates autophagy in chondrocytes to improve osteoarthritis in rats

Osteoarthritis (OA) is a degenerative disease that seriously affects an individual's quality of life. Oleanolic acid (OLA) is widely present in food and medicinal plants and has various pharmacological activities. Autophagy is an intracellular protective mechanism, and this study aimed to inves...

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Bibliographic Details
Main Authors: Yue Yu, Tianwen Ma, Liangyu Lv, Lina Jia, Hongri Ruan, Hong Chen, Jiantao Zhang, Li Gao
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Journal of Functional Foods
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464622002146