Multifunctional Gomisin B enhances cognitive function in APP/PS1 transgenic mice by regulating Aβ clearance and neuronal apoptosis

Multifunctional Gomisin B enhances cognitive function in APP/PS1 transgenic mice by regulating Aβ clearance and neuronal apoptosis

This study aimed to investigate the potential effects of Gomisin B, a natural compound known for its inhibition of CYP3A4, on cognitive dysfunction in APP/PS1 transgenic mice with Alzheimer's disease (AD). Additionally, the study explored the combined effects of Gomisin B and Osthole (OST). The...

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Bibliographic Details
Main Authors: Jinman Liu, Xue Zuo, Mingjun Huang, Jiansong Fang, Weirong Li, Qing Shi, Qi Wang, Yong Liang
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Alzheimer's disease
Gomisin B
Osthole
APP/PS1 transgenic mice
Oxidative stress
Neuronal apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223012210

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http://www.sciencedirect.com/science/article/pii/S0753332223012210

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