Multifunctional Gomisin B enhances cognitive function in APP/PS1 transgenic mice by regulating Aβ clearance and neuronal apoptosis

Multifunctional Gomisin B enhances cognitive function in APP/PS1 transgenic mice by regulating Aβ clearance and neuronal apoptosis

This study aimed to investigate the potential effects of Gomisin B, a natural compound known for its inhibition of CYP3A4, on cognitive dysfunction in APP/PS1 transgenic mice with Alzheimer's disease (AD). Additionally, the study explored the combined effects of Gomisin B and Osthole (OST). The...

Full description

Bibliographic Details
Main Authors:	Jinman Liu, Xue Zuo, Mingjun Huang, Jiansong Fang, Weirong Li, Qing Shi, Qi Wang, Yong Liang
Format:	Article
Language:	English
Published:	Elsevier 2023-10-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Alzheimer's disease Gomisin B Osthole APP/PS1 transgenic mice Oxidative stress Neuronal apoptosis
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332223012210

Similar Items

Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice
by: Fanchang Wu, et al.
Published: (2023-07-01)

N-linoleyltyrosine exerts neuroprotective effects in APP/PS1 transgenic mice via cannabinoid receptor-mediated autophagy
by: Chun-mei Long, et al.
Published: (2021-12-01)

Effects of Qi-Fu-Yin on aging of APP/PS1 transgenic mice by regulating the intestinal microbiome
by: Qiu-yue Xiao, et al.
Published: (2023-01-01)

Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation
by: Kun Cao, et al.
Published: (2019-04-01)

Effects of 50 Hz magnetic field exposure on metabolism of cerebral cortex in APP/PS1 transgenic mice
by: ZHANG Yanwen, et al.
Published: (2023-02-01)

Gastrodin as a multi-target protective compound reverses learning memory deficits and AD-like pathology in APP/PS1 transgenic mice
by: Yue-Qin Zeng, et al.
Published: (2021-02-01)

Effects of Oligosaccharides From Morinda officinalis on Gut Microbiota and Metabolome of APP/PS1 Transgenic Mice
by: Yang Xin, et al.
Published: (2018-06-01)

Fluoxetine Promotes Hippocampal Oligodendrocyte Maturation and Delays Learning and Memory Decline in APP/PS1 Mice
by: Feng-lei Chao, et al.
Published: (2021-01-01)

Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice
by: Haiwang Zhang, et al.
Published: (2021-07-01)

Time- and NADPH-Dependent Inhibition on CYP3A by Gomisin A and the Pharmacokinetic Interactions between Gomisin A and Cyclophosphamide in Rats
by: Jianxiu Zhai, et al.
Published: (2017-08-01)

Action of the natural compound gomisin a on Ca2+ movement in human prostate cancer cells
by: Lyh-Jyh Hao, et al.
Published: (2022-01-01)

Phosphorylation of Tau at S422 is enhanced by Aβ in TauPS2APP triple transgenic mice
by: Fiona Grueninger, et al.
Published: (2010-02-01)

Pathological and Synaptic Morphological Changes of the Olfactory Bulb in APP/PS1 Model Mice at Different Ages and the Intervention Effect of Memantine
by: LIU Jiani, et al.
Published: (2022-06-01)

Preliminary study on early diagnosis of Alzheimer’s disease in APP/PS1 transgenic mice using multimodal magnetic resonance imaging
by: Meng Xu, et al.
Published: (2024-02-01)

Total ginsenoside and Acorus tatarinowii volatile oil co-administration reverses learning memory deficits, reduces Aβ42 and AChE levels, and downregulates the PI3K/Akt/mTOR/Beclin-1 autophagic pathway in APP/PS1 double transgenic mice
by: Minzhen Deng, et al.
Published: (2022-03-01)

Gomisin L1, a Lignan Isolated from Schisandra Berries, Induces Apoptosis by Regulating NADPH Oxidase in Human Ovarian Cancer Cells
by: Young Hyun Ko, et al.
Published: (2021-08-01)

Gomisin A Suppresses Colorectal Lung Metastasis by Inducing AMPK/p38-Mediated Apoptosis and Decreasing Metastatic Abilities of Colorectal Cancer Cells
by: Ji-Ye Kee, et al.
Published: (2018-08-01)

Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling
by: Lei Li, et al.
Published: (2020-02-01)

Gomisin N ameliorates lipopolysaccharide-induced depressive-like behaviors by attenuating inflammation in the hypothalamic paraventricular nucleus and central nucleus of the amygdala in mice
by: Ryota Araki, et al.
Published: (2016-10-01)

Examination of Longitudinal Alterations in Alzheimer’s Disease-Related Neurogenesis in an APP/PS1 Transgenic Mouse Model, and the Effects of P33, a Putative Neuroprotective Agent Thereon
by: Titanilla Szögi, et al.
Published: (2022-09-01)

EK100 and Antrodin C Improve Brain Amyloid Pathology in APP/PS1 Transgenic Mice by Promoting Microglial and Perivascular Clearance Pathways
by: Huey-Jen Tsay, et al.
Published: (2021-09-01)

Intermittent hypoxia improves cognition and reduces anxiety‐related behavior in APP/PS1 mice
by: Sheng‐Xi Meng, et al.
Published: (2020-02-01)

Functional Characterization of Gomisin N in High-Fat-Induced <i>Drosophila</i> Obesity Models
by: Joo Young Lee, et al.
Published: (2020-09-01)

Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span
by: Markus von Kienlin, et al.
Published: (2005-02-01)

YXQN Reduces Alzheimer’s Disease-Like Pathology and Cognitive Decline in APPswePS1dE9 Transgenic Mice
by: Xiaowan Wang, et al.
Published: (2017-05-01)

Low-Dose Delta-9-Tetrahydrocannabinol as Beneficial Treatment for Aged APP/PS1 Mice
by: Yanhong Wang, et al.
Published: (2022-03-01)

Gomisin M2 Inhibits Mast Cell-Mediated Allergic Inflammation via Attenuation of FcεRI-Mediated Lyn and Fyn Activation and Intracellular Calcium Levels
by: Hima Dhakal, et al.
Published: (2019-08-01)

Long-term exercise training inhibits inflammation by suppressing hippocampal NLRP3 in APP/PS1 mice
by: Xue Li, et al.
Published: (2023-12-01)

Suan-Zao-Ren Decoction ameliorates synaptic plasticity through inhibition of the Aβ deposition and JAK2/STAT3 signaling pathway in AD model of APP/PS1 transgenic mice
by: Qing-Hua Long, et al.
Published: (2021-01-01)

Paeonol administration alleviates cognitive deficits and attenuates neural pathological changes in APP/PS1 mice
by: Shengxi Meng, et al.
Published: (2021-12-01)

Nasal delivery of a CRMP2-derived CBD3 adenovirus improves cognitive function and pathology in APP/PS1 transgenic mice
by: Baochang Qi, et al.
Published: (2020-04-01)

Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice
by: Qiang Su, et al.
Published: (2024-03-01)

Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD)
by: C.R. Hooijmans, et al.
Published: (2007-10-01)

Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice
by: Céline Héraud, et al.
Published: (2014-02-01)

Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APPswe/PS1dE9 transgenic mice: Effect of long-term treatment with paroxetine
by: Louise Ørum Olesen, et al.
Published: (2017-08-01)

Gamma radiation improves AD pathogenesis in APP/PS1 mouse model by potentiating insulin sensitivity
by: Mayuri Khandelwal, et al.
Published: (2020-07-01)

The Aβ Containing Brain Extracts Having Different Effects in Alzheimer’s Disease Transgenic Caenorhabditis elegans and Mice
by: Yufang Yang, et al.
Published: (2018-07-01)

Lentivirus-Carried microRNA-195 Rescues Memory Deficits of Alzheimer’s Disease Transgenic Mouse by Attenuating the Generation of Amyloid Plaques
by: Dan Su, et al.
Published: (2021-04-01)

Vitamin A Deficiency Exacerbates Gut Microbiota Dysbiosis and Cognitive Deficits in Amyloid Precursor Protein/Presenilin 1 Transgenic Mice
by: Bo-Wen Chen, et al.
Published: (2021-11-01)

Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice
by: Xuewang Li, et al.
Published: (2023-04-01)